Two simple, sensitive, accurate and economical spectrophotometric methods were developed for the estimation of mebevrine hydrochloride (MB) and chlordiazepoxide (CLR) simultaneously in tablet dosage form.First method is based on the simultaneous equations and second method is based on Q-analysis (absorbance ratio method). Mebeverine hydrochloride and chlordiazepoxide shows absorbance maxima at 220.0 nm and 264.5 nm in methanol, respectively. The linearity was obtained in the concentration range of 2-12 µg/ml for MB and 1-10 µg/ml for CLR. In the first method, the concentrations of the drugs were determined by using simultaneous equations; and in the second method, the concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λmax of the one drug.Statistical validation of the data has been carried out and it reveals that the proposed method is sensitive and economical too for the routine analysis of the drugs in combined dosage form.
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